Most eukaryotic chromosomes bend back on themselves to type a physical loop for the telomere. The existence of these loops, aptly named t-loops, was initially proven by electron microscopy of purified human telomeres that were stripped of their proteins and stabilized by crosslinking (Griffith et al. Telomeres shorten with age https://paxtonlfqwf.thekatyblog.com/27715226/considerations-to-know-about-fox-eyes-red