Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON state�? On ligation of Wnts to their receptors made up of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates into your nucleus and binds to TCF/LEF transcription variables https://georgesl912dby0.blogozz.com/profile