Opioid action is because of both small affinity binding from the parent compound and better affinity binding on the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is approximately 6 periods much more strong than tramadol in manufacturing analgesia and 200 moments more potent in μ-opioid binding. Use https://mariew029sni0.tdlwiki.com/user