Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interacti... https://lorenzi207biq4.mysticwiki.com/user