If a mum or dad of your proband is known to contain the pathogenic variant recognized inside the proband, the danger on the sibs of inheriting the pathogenic variant is 50%. On account of lowered penetrance, sibs who inherit the pathogenic variant might or might not produce aHUS (see Penetrance). https://donovanblubi.activablog.com/31264171/the-smart-trick-of-air-handling-units-ahus-that-no-one-is-discussing