A comprehensive literature review of studies involving 1995 and 2018 was conducted using the electronic databases PubMed and EBSCO Host. Queries ended up executed making use of the next phrases: total knee arthroplasty (TKA); cyclooxygenase-2 inhibitors; bracing; physical therapy; fat loss; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; corticosteroid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/