There's a launch of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to decrease afferent discomfort transmission and develop analgesia. Thus, medicine like clonidine that target alpha-two receptors can affect the transmission of discomfort. : linked to, served by, or accessible through https://mixbookmark.com/story5425542/onolidine-an-overview